Article

Playing Musical Chairs in Big Data to Reveal Variables’ Associations

2016-06-05

Abstract excerpt

Testing for associations in big data faces the problem of multiple comparisons, with true signals buried inside the noise of all associations queried. This is particularly true in genetic association studies where a substantial proportion of the variation of human phenotypes is driven by numerous genetic variants of small effect. The current strategy to improve power to identify these weak associations consists of...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 5691fb80-c309-5dc8-a7e7-3ea04e608604
DOI: 10.1101/057190

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Playing Musical Chairs in Big Data to Reveal Variables’ AssociationsDOI 10.1101/057190Read

Covariate selection for association screening in multiphenotype genetic studies.Semantic proximity Read

Genetic association of high-dimensional traitsSemantic proximity Read

A simple approach for multiple observations improves power to detect genetic effects and genomic prediction accuracy.Semantic proximity Read

A Scalable Framework to Integrate Social Determinants of Health into Disease Risk Models using Biobank Survey DataSemantic proximity Read

Observational epidemiological studies can mitigate genetic confounding with a genetic relatedness matrixSemantic proximity Read

Detecting gene-environment interactions from multiple continuous traits.Semantic proximity Read

Transethnic Genetic-Correlation Estimates from Summary Statistics.Semantic proximity Read

Integrating social determinants of health and genetic risk in disease risk models.Semantic proximity Read

Widespread signatures of negative selection in the genetic architecture of human complex traitsSemantic proximity Read

Observational epidemiological studies can mitigate genetic confounding with a genetic relatedness matrix.Semantic proximity Read

Sparse modeling of interactions enables fast detection of genome-wide epistasis in biobank-scale studiesSemantic proximity Read

Gene-Gene Interaction Detection with Deep LearningSemantic proximity Read