Article

Novel syngeneic animal model of tobacco-associated oral cancer reveals the activity of <i>in situ</i> anti-CTLA-4

2019-06-15

Abstract excerpt

Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer worldwide. Tobacco use is the main risk factor for HNSCC, and tobacco-associated HNSCCs have poor prognosis and response to available treatments. Recently approved anti-PD-1 immune checkpoint inhibitors showed limited activity (≤20%) in HNSCC, highlighting the need to identify new therapeutic options. For this, mouse models that accurate...

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Identifiers and source

Literature Corpus work: 04fa132f-babb-5f56-a784-9eb551de4910
DOI: 10.1101/672527

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