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Article

Syngeneic tobacco carcinogen-induced mouse lung adenocarcinoma model exhibits PD-L1 expression and high tumor mutational burden.

JCI insight - 8 Feb 2021

Stabile Laura P, Kumar Vinod, Gaither-Davis Autumn, Huang Eric H, Vendetti Frank P, Devadassan Princey, Dacic Sanja, Bao Riyue, Steinman Richard A, Burns Timothy F, Bakkenist Christopher J

Abstract excerpt

Human lung adenocarcinoma (LUAD) in current or former smokers exhibits a high tumor mutational burden (TMB) and distinct mutational signatures. Syngeneic mouse models of clinically relevant smoking-related LUAD are lacking. We established and characterized a tobacco-associated, transplantable murine LUAD cell line, designated FVBW-17, from a LUAD induced by the tobacco carcinogen...

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Identifiers

PMID: 33351788
DOI: 10.1172/jci.insight.145307
PMCID: PMC7934870

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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