Article

Single-cell RNA profiling suggests goflikicept-mediated immune modulation in idiopathic recurrent pericarditis

2025-09-23

Abstract excerpt

<title>Abstract</title> <p>Idiopathic recurrent pericarditis (IRP) is a rare autoinflammatory disorder characterized by NLRP3 inflammasome overactivation, resulting in excessive IL-1β and IL-1α production. Although IL-1 blockade shows promise as a therapeutic strategy, the underlying molecular mechanisms remain incompletely understood. We investigated the effect of goflikicept, a novel heterodimeric fusion protei...

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Literature Corpus work: 04f3895c-5f3e-5bda-821d-a90c1ab033cb
DOI: 10.21203/rs.3.rs-7507778/v1

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