Article
Variants at the Interleukin 1 Gene Locus and Pericarditis.
JAMA cardiology - 1 Feb 2024
Thorolfsdottir Rosa B, Jonsdottir Andrea B, Sveinbjornsson Gardar, Aegisdottir Hildur M, Oddsson Asmundur, Stefansson Olafur A, Halldorsson Gisli H, Saevarsdottir Saedis, Thorleifsson Gudmar, Stefansdottir Lilja, Pedersen Ole B, Sørensen Erik, Ghouse Jonas, Raja Anna Axelsson, Zheng Chaoqun, Silajdzija Elvira, Rand Søren Albertsen, Erikstrup Christian, Ullum Henrik, Mikkelsen Christina, Banasik Karina, Brunak Søren, Ivarsdottir Erna V, Sigurdsson Asgeir, Beyter Doruk, Sturluson Arni, Einarsson Hafsteinn, Tragante Vinicius, Helgason Hannes, Lund Sigrun H, Halldorsson Bjarni V, Sigurpalsdottir Brynja D, Olafsson Isleifur, Arnar David O, Thorgeirsson Gudmundur, Knowlton Kirk U, Nadauld Lincoln D, Gretarsdottir Solveig, Helgadottir Anna, Ostrowski Sisse R, Gudbjartssson Daniel F, Jonsdottir Ingileif, Bundgaard Henning, Holm Hilma, Sulem Patrick, Stefansson Kari
Abstract excerpt
Importance: Recurrent pericarditis is a treatment challenge and often a debilitating condition. Drugs inhibiting interleukin 1 cytokines are a promising new treatment option, but their use is based on scarce biological evidence and clinical trials of modest sizes, and the contributions of innate and adaptive immune processes to the pathophysiology are incompletely understood. Objective: To use human genomics,...
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