Article

Mapping Structural Aging of Human Tissue reveals tissue-specific trajectories and coordinated deterioration

2025-10-01

Abstract excerpt

1. Tissue structure, the organization of cells, vasculature and extracellular matrix, underpins organ function. Yet how it deteriorates with age remains largely uncharacterized. Current aging research focuses primarily on molecular changes, missing this structural dimension. Here we present PathStAR (Pathology-based Structural Aging Rate), a computational framework that quantifies tissue structural aging from hist...

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Literature Corpus work: 04cda46c-10ae-5667-9ae6-6104ef499d9d
DOI: 10.1101/2025.09.29.679316

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