Article

Heterogeneous aging across multiple organ systems and prediction of chronic disease and mortality

2022-09-04

Abstract excerpt

Biological aging of human organ systems reflects the interplay of age, chronic disease, lifestyle and genetic risk. Using longitudinal brain imaging and physiological phenotypes from the UK Biobank, we establish normative models of biological age for 3 brain and 7 body systems. We find that an organ’s biological age selectively influences the aging of other organ systems, revealing a multiorgan aging network. We r...

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Literature Corpus work: 3d0004a7-ad66-5e48-81f0-fbeba51b757c
DOI: 10.1101/2022.09.03.22279337

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