Article

The ERBB network facilitates KRAS-driven lung tumorigenesis

2018-04-09

Abstract excerpt

KRAS is the most frequently mutated driver oncogene in human adenocarcinoma of the lung. There are presently no clinically proven strategies for treatment of KRAS-driven lung cancer. Activating mutations in KRAS are thought to confer independence from upstream signaling, however recent data suggest that this independence may not be absolute. Here we show that initiation and progression of KRAS-driven lung tumors r...

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Literature Corpus work: 04bca95a-55b3-5a3e-a06f-83059a49ecb2
DOI: 10.1101/290700

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