Article
Epithelial-to-Mesenchymal Transition Defines Feedback Activation of Receptor Tyrosine Kinase Signaling Induced by MEK Inhibition in KRAS-Mutant Lung Cancer.
Cancer discovery - 1 Jul 2016
Kitai Hidenori, Ebi Hiromichi, Tomida Shuta, Floros Konstantinos V, Kotani Hiroshi, Adachi Yuta, Oizumi Satoshi, Nishimura Masaharu, Faber Anthony C, Yano Seiji
Abstract excerpt
UNLABELLED: KRAS is frequently mutated in lung cancer. Whereas MAPK is a well-known effector pathway of KRAS, blocking this pathway with clinically available MAPK inhibitors is relatively ineffective. Here, we report that epithelial-to-mesenchymal transition rewires the expression of receptor tyrosine kinases, leading to differential feedback activation of the MAPK pathway following MEK inhibition. In...
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