Article

Quantitative determination of longitudinal CNS cholesterol loss during myelin damage and repair

2026-06-09

Abstract excerpt

1. <h4>ABSTRACT</h4> Cholesterol in the central nervous system (CNS) is largely unesterified (>99%) and is predominantly present in the myelin sheath (∼70% of total CNS cholesterol). Damage to the myelin sheath can result in the conversion of cholesterol to cholesterol esters, which occurs in many neurological diseases, including multiple sclerosis. In this study, we measured longitudinal CNS free cholesterol and...

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Literature Corpus work: 04b20d5b-aa13-559d-830b-9d4e76a49ad3
DOI: 10.64898/2026.06.04.729895

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