Article
Oligodendroglial myelination requires astrocyte-derived lipids.
PLoS biology - 1 May 2017
Camargo Nutabi, Goudriaan Andrea, van Deijk Anne-Lieke F, Otte Willem M, Brouwers Jos F, Lodder Hans, Gutmann David H, Nave Klaus-Armin, Dijkhuizen Rick M, Mansvelder Huibert D, Chrast Roman, Smit August B, Verheijen Mark H G
Abstract excerpt
In the vertebrate nervous system, myelination of axons for rapid impulse propagation requires the synthesis of large amounts of lipids and proteins by oligodendrocytes and Schwann cells. Myelin membranes are thought to be cell-autonomously assembled by these axon-associated glial cells. Here, we report the surprising finding that in normal brain development, a substantial fraction of the lipids incorporated into...
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