Article
Mutation of 3-hydroxy-3-methylglutaryl CoA synthase I reveals requirements for isoprenoid and cholesterol synthesis in oligodendrocyte migration arrest, axon wrapping, and myelin gene expression.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 26 Feb 2014
Mathews Emily S, Mawdsley David J, Walker Macie, Hines Jacob H, Pozzoli Marina, Appel Bruce
Abstract excerpt
Myelin membrane, which ensheaths axons, has an unusually high amount of cholesterol. Cholesterol influences membrane fluidity and assembles lipid-rich microdomains within membranes, and some studies have shown that cholesterol is important for myelination. How cholesterol influences the development and differentiation of oligodendrocytes, glial cells that make myelin, is not known nor is clear whether...
Topics
- Animals
- Animals, Genetically Modified
- Axons
- Body Patterning
- Cell Movement
- Cholesterol
- Embryo, Nonmammalian
- Enzyme Inhibitors
- Gene Expression
- Green Fluorescent Proteins