Back to search

Article

ALOXE3 is a hepatic fasting-responsive lipoxygenase that enhances insulin sensitivity via hepatic PPARγ

2018-02-19

Abstract excerpt

<h4>ABSTARCT</h4> The hepatic glucose fasting response is gaining traction as a therapeutic pathway to enhance hepatic and whole-host metabolism. However, the mechanisms underlying these metabolic effects remain unclear. Here, we demonstrate the lipoxygenase, ALOXE3, is a novel effector of the thepatic fasting response. We show that ALOXE3 is activated during fasting, glucose withdrawal, and trehalose/trehalose a...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
04a1751c-396c-5f22-9fcb-88ec1fef94fb
DOI
10.1101/267781
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
ALOXE3 is a hepatic fasting-responsive lipoxygenase that enhances insulin sensitivity via hepatic PPARγDOI 10.1101/267781
Hepatic aldose reductase drives a Warburg effect-like metabolic reprogramming to promote insulin resistance, fatty liver and obesitySemantic proximity
Genome-Wide Transcriptome Analysis Reveals Intermittent Fasting-Induced Metabolic Rewiring in the LiverSemantic proximity
Sex- and ketogenesis-dependent effects of intermittent fasting against diet-induced obesity and fatty liver diseaseSemantic proximity
Beneficial effects of intermittent fasting in NASH and subsequent HCC development are executed by concerted PPARα and PCK1 action in hepatocytesSemantic proximity
A multiomics comparison of weight loss interventions shows the distinct effects of bariatric surgery and intermittent fasting on hepatic metabolismSemantic proximity
Fructose Induced KHK-C Increases ER Stress and Modulates Hepatic Transcriptome to Drive Liver Disease in Diet-Induced and Genetic Models of NAFLDSemantic proximity
Vitamin B2 enables peroxisome proliferator-activated receptor α regulation of fasting glucose availabilitySemantic proximity
Chronic exposure to IL6 leads to deregulation of glycolysis and fat accumulation in the zebrafish liverSemantic proximity
From Carbohydrates to Ketones: Mitochondrial Reprogramming via β-Hydroxybutyrate Signaling for Non-Pharmacological Treatment of Metabolic SyndromeSemantic proximity
Genome-Wide mRNA Expression Analysis of Hepatic Adaptation to High-Fat Diets Reveals Switch from an Inflammatory to Steatotic Transcriptional ProgramSemantic proximity
A common East-Asian ALDH2 mutation causes metabolic disorders and the therapeutic effect of ALDH2 activators.Semantic proximity
A common East Asian-specific ALDH2 mutation causes obesity and insulin resistance: therapeutic effect of reducing toxic aldehydes by ALDH2 activationSemantic proximity
Select a neighboring publication to make it the new centre.