Article

MSGene: Derivation and validation of a multistate model for lifetime risk of coronary artery disease using genetic risk and the electronic health record

2023-11-08

Abstract excerpt

Currently, coronary artery disease (CAD) is the leading cause of death among adults worldwide. Accurate risk stratification can support optimal lifetime prevention. We designed a novel and general multistate model (MSGene) to estimate age-specific transitions across 10 cardiometabolic states, dependent on clinical covariates and a CAD polygenic risk score. MSGene supports decision making about CAD prevention relat...

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Literature Corpus work: 049db3cf-a6b2-5b09-8ff0-603a44d1d6e9
DOI: 10.1101/2023.11.08.23298229

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