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Article

MSGene: a multistate model using genetic risk and the electronic health record applied to lifetime risk of coronary artery disease.

Nature communications - 7 Jun 2024

Urbut Sarah M, Yeung Ming Wai, Khurshid Shaan, Cho So Mi Jemma, Schuermans Art, German Jakob, Taraszka Kodi, Paruchuri Kaavya, Fahed Akl C, Ellinor Patrick T, Trinquart Ludovic, Parmigiani Giovanni, Gusev Alexander, Natarajan Pradeep

Abstract excerpt

Coronary artery disease (CAD) is the leading cause of death among adults worldwide. Accurate risk stratification can support optimal lifetime prevention. Current methods lack the ability to incorporate new information throughout the life course or to combine innate genetic risk factors with acquired lifetime risk. We designed a general multistate model (MSGene) to estimate age-specific transitions across 10...

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Identifiers

PMID: 38849421
DOI: 10.1038/s41467-024-49296-9
PMCID: PMC11161589

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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