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Article

Amino Acid Variants of HLA-DRB1 Confer Susceptibility to Dapsone Hypersensitivity Syndrome in Addition to HLA-B*13:01.

The Journal of investigative dermatology - 1 May 2018

Yue Zhenhua, Sun Yonghu, Wang Chuan, Yu Wenjun, Cao Jing, Bao Fangfang, Wang Zhenzhen, Liu Hong, Zhang Furen

Abstract excerpt

Dapsone hypersensitivity syndrome is a rare yet severe adverse drug reaction caused by dapsone, a principal drug in multidrug therapy for leprosy. HLA-B*13:01 has been identified as a strong risk factor of dapsone hypersensitivity syndrome; however, its low positive predictive value indicated that additional genetic variants may be involved in the disease development. To discover contributing genetic variants...

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Identifiers

PMID: 29233746
DOI: 10.1016/j.jid.2017.11.027

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Amino Acid Variants of HLA-DRB1 Confer Susceptibility to Dapsone Hypersensitivity Syndrome in Addition to HLA-B*13:01.PMID 29233746Read ↗

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