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Article

Neurodegenerative and inflammatory pathway components linked to TNF-α/TNFR1 signaling in the glaucomatous human retina.

Investigative ophthalmology & visual science - 31 Oct 2011

Yang Xiangjun, Luo Cheng, Cai Jian, Powell David W, Yu Dahai, Kuehn Markus H, Tezel Gülgün

Abstract excerpt

PURPOSE: This study aimed to determine retinal proteomic alterations in human glaucoma, with particular focus on links to TNF-α/TNFR1 signaling. METHODS: Human retinal protein samples were obtained from 20 donors with (n = 10) or without (n = 10) glaucoma. Alterations in protein expression were individually analyzed by quantitative LC-MS/MS. Quantitative Western blot analysis with cleavage or phosphorylation...

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Source

Open in PubMed Open full text

Identifiers

PMID: 21917936
DOI: 10.1167/iovs.11-8152
PMCID: PMC3208177

Genes

TNF
TNFAIP3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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