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Pyroptosis and degenerative diseases of the elderly

8 Feb 2023

Abstract excerpt

Pyroptosis is a recently described mechanism of programmed cell death mediated by proteins of the gasdermin family. Widely recognized signaling cascades include the classical, non-classical, caspase-3-dependent gasdermin E and caspase-8-dependent gasdermin D pathways. Additional pyroptotic pathways have been subsequently reported. With the rising prevalence of advanced age, the role of pyroptosis in the...

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PMID: 36755014
DOI: 10.1038/s41419-023-05634-1

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