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Article

Targeting Necroptosis: A Novel Therapeutic Option for Retinal Degenerative Diseases

1 Jan 2023

Abstract excerpt

The discovery of the necroptosis, a form of regulated necrosis that is mediated by receptor-interacting protein kinase 1 (RIPK1), RIPK3, and mixed-lineage kinase domain-like pseudokinase (MLKL), represents a major breakthrough that has dramatically altered the conception of necrosis -traditionally thought of as uncontrolled cell death -in various human diseases. Retinal cell death is a leading cause of blindness...

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PMID: 36632450
DOI: 10.7150/ijbs.77994

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