Article

OXT neuron-specific CAPS2 deficiency in mice impairs hippocampal plasticity and long-term memory through reduced ERK phosphorylation in the ventral hippocampus

2025-12-05

Abstract excerpt

Oxytocin (OXT), a neuropeptide produced in the paraventricular nucleus (PVN) of the hypothalamus, regulates social behavior, stress responses, and memory. Our previous studies demonstrated that intracerebroventricular administration of OXT ameliorates amyloid-β–induced cognitive deficits and that selective activation of PVN OXT neurons enhances memory performance. These findings suggest that endogenous OXT secreti...

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Literature Corpus work: 0438d366-a4f6-5654-8f3a-f9a4ad52ac81
DOI: 10.22541/au.176494000.08749304/v1

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