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Article

The APP-interacting protein FE65 is required for hippocampus-dependent learning and long-term potentiation.

Learning & memory (Cold Spring Harbor, N.Y.) - 1 Sept 2009

Wang Yan, Zhang Ming, Moon Changjong, Hu Qubai, Wang Baiping, Martin George, Sun Zhongsheng, Wang Hongbing

Abstract excerpt

FE65 is expressed predominantly in the brain and interacts with the C-terminal domain of beta-amyloid precursor protein (APP). We examined hippocampus-dependent memory and in vivo long-term potentiation (LTP) at the CA1 synapses with isoform-specific FE65 knockout (p97FE65(-/-)) mice. When examin...

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Source

Identifiers

PMID: 19713352
DOI: 10.1101/lm.1499309

Genes

APP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19713352-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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