Article

The sodium/glucose cotransporter 2 inhibitor empagliflozin is a pharmacological chaperone of cardiac Na <sub>v</sub> 1.5 channels

2025-05-19

Abstract excerpt

<h4>ABSTRACT</h4> Diminished peak sodium current (I Na ) is a causative factor for slowed ventricular conduction and cardiac arrhythmias in patients with Duchenne muscular dystrophy (DMD), a devastating muscle disease triggered by dystrophin deficiency. Recently, we showed that chronic administration of the sodium/glucose cotransporter 2 (SGLT2) inhibitor empagliflozin (EMPA) restores diminished peak I Na in ve...

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Literature Corpus work: 04201427-e373-5d46-a511-1da7d70b64aa
DOI: 10.1101/2025.05.15.654221

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