Article
Voltage-gated ion channel dysfunction precedes cardiomyopathy development in the dystrophic heart.
PloS one - 1 Jan 2011
Koenig Xaver, Dysek Sandra, Kimbacher Stefanie, Mike Agnes K, Cervenka Rene, Lukacs Peter, Nagl Katrin, Dang Xuan B, Todt Hannes, Bittner Reginald E, Hilber Karlheinz
Abstract excerpt
BACKGROUND: Duchenne muscular dystrophy (DMD), caused by mutations in the dystrophin gene, is associated with severe cardiac complications including cardiomyopathy and cardiac arrhythmias. Recent research suggests that impaired voltage-gated ion channels in dystrophic cardiomyocytes accompany cardiac pathology. It is, however, unknown if the ion channel defects are primary effects of dystrophic gene mutations, or...
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