Back to search

Article

Brain imaging data and summary-data-based Mendelian randomization analysis reveal the impact of multiorgan aging on schizophrenia

2026-02-03

Abstract excerpt

<title>Abstract</title> <p> Aim The adverse health outcomes of schizophrenia (SZ) are largely driven by the high prevalence of other non-neurological diseases. In addition to accelerated brain aging, patients with SZ also exhibit signs of systemic aging. However, the potential causal or biological mechanisms between multisystem aging and schizophrenia remain unknown. Methods We obtained SZ-associated single Nu...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
03f9b4a2-7804-5ce6-bd27-407115c85b41
DOI
10.21203/rs.3.rs-7922183/v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Brain imaging data and summary-data-based Mendelian randomization analysis reveal the impact of multiorgan aging on schizophreniaDOI 10.21203/rs.3.rs-7922183/v1
Genetic influence of the brain on epigenetic age acceleration: evidence of a large-scale genetic correlation study.Semantic proximity
The Relationship Between Frailty and Schizophrenia: A Genetic Association and Mendelian Randomization StudySemantic proximity
Summary-data-based Mendelian Randomization Analysis Identifies Nominal Evidence for Association of N6-Methyladenosine Genetic Variation with Alzheimer's Disease.Semantic proximity
Mendelian Randomization Study Using Dopaminergic Neuron-Specific eQTL Identifies Novel Risk Genes for Schizophrenia.Semantic proximity
Epigenetic age acceleration and prevalent age- related neurological disorders: a two-sample Mendelian randomization studySemantic proximity
Autophagic molecular network in IS pathogenesis: A multi-omics Mendelian randomization study.Semantic proximity
Brain molecular aging, promotion of neurological disease and modulation by sirtuin 5 longevity gene polymorphism.Semantic proximity
Meta-analyses of epigenetic age acceleration and GrimAge components of schizophrenia or first-episode psychosisSemantic proximity
Assessing causal associations between neurodegenerative diseases and neurological tumors with biological aging: a bidirectional Mendelian randomization studySemantic proximity
Novel DNA methylation loci and genes showing pleiotropic association with Alzheimer's dementia: a network Mendelian randomization analysis.Semantic proximity
Epigenetic age is accelerated in schizophrenia with age- and sex-specific effects and associated with polygenic disease riskSemantic proximity
Systematic comparative analysis of Mendelian randomization methods for inferring causal genes of complex phenotypes and the application to psychiatric diseasesSemantic proximity
Select a neighboring publication to make it the new centre.