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Article

Genetic influence of the brain on epigenetic age acceleration: evidence of a large-scale genetic correlation study.

Biogerontology - 28 Aug 2025

Li Chengcheng, Tang Jiaze, Cui Junshuan, Long Niya, Cen Wu, Wu Qibo, Yang Ming, Chu Liangzhao, Zhou Xingwang

Abstract excerpt

The relationship between the brain and aging remains unclear. Our objective is to explore the causal connections between brain structure,gene expression, and traits associated with aging. Mendelian randomization(MR) analysis was conducted to explore the associations between brain structures and aging-related traits including GrimAge acceleration(GrimAA), PhenoAge acceleration (PhenoAA), HannumAge...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40875050
DOI: 10.1007/s10522-025-10314-y

Genes

FAIM
OGFOD3
SHMT1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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