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A human tissue‐specific transcriptomic analysis reveals a complex relationship between aging, cancer, and cellular senescence

27 Sept 2019

Abstract excerpt

Aging is the biggest risk factor for cancer, but the mechanisms linking these two processes remain unclear. Using GTEx and TCGA data, we compared genes differentially expressed with age and genes differentially expressed in cancer among nine human tissues. In most tissues, aging and cancer gene expression pattern changed in the opposite direction. The exception was thyroid and uterus, where we found...

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Share to Epigenetics and DNA Methylation
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PMID: 31560156
DOI: 10.1111/acel.13041

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