Article

TMX1, a disulfide oxidoreductase, is necessary for T cell function through regulation of CD3ζ

2024-09-24

Abstract excerpt

<h4>ABSTRACT</h4> T cell-targeted therapies are commonly used to manage T cell hyperactivity in autoimmune disorders, graft-versus-host diseases (GVHD), and transplant rejections. However, many patients experience significant side effects or inadequate responses to current treatments, highlighting the urgent need for alternative strategies. In this study, we searched for regulators of T cells through proximity la...

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Literature Corpus work: 03b1405a-2749-50a2-9915-ed5a36afd972
DOI: 10.1101/2024.09.22.614388

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