Article

Interpretable AI Decision-Support for Pre-IND Drug Development in a Historically Animal-Approved Cohort: A Large Concept Model Framework

2026-05-20

Abstract excerpt

<title>Abstract</title> <p>Background Preclinical animal models remain the dominant basis for early drug-development Go/No-Go decisions, yet their translational reliability is limited, and many programs entering human trials ultimately fail. This study evaluates whether a mechanistic, human-centric artificial intelligence framework can provide improved translational decision support using the same pre-IND inform...

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Literature Corpus work: 038770ab-e65f-5ed0-b1a2-5ba300210960
DOI: 10.21203/rs.3.rs-9473758/v1

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