Article

From Computational Prediction to In Vivo Experimental Validation: A Translational AI Pipeline for Anthracycline-Induced Cardiotoxicity

2026-08-13

Abstract excerpt

<title>Abstract</title> <p> Anthracycline-induced cardiotoxicity (AIC) remains a dose-limiting complication of cancer treatment, often leading to irreversible heart failure, yet effective cardioprotective therapies remain limited. Graph-driven drug repurposing offers a rapid pathway to identify cardioprotective therapies, but different computational models often generate divergent candidate lists that exceed exp...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 813b1dfb-11f9-5a4a-981c-75582e6215eb
DOI: 10.21203/rs.3.rs-10594011/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

From Computational Prediction to In Vivo Experimental Validation: A Translational AI Pipeline for Anthracycline-Induced CardiotoxicityDOI 10.21203/rs.3.rs-10594011/v1Read

Interpretable AI Decision-Support for Pre-IND Drug Development in a Historically Animal-Approved Cohort: A Large Concept Model FrameworkSemantic proximity Read

Multilayered validation of graph attention autoencoder–derived drug repurposing candidates for COVID-19Semantic proximity Read

Novel graph attention autoencoder framework with multilayered validation identifies drug repurposing candidates for COVID-19 treatmentSemantic proximity Read

Systematic integration of biomedical knowledge prioritizes drugs for repurposingSemantic proximity Read

Deep Learning Predicts Patterns of Cardiotoxicity in a High-Content Screen Using Induced Pluripotent Stem Cell–Derived CardiomyocytesSemantic proximity Read

predicTox: An integrated database of clinical risk frequencies and human gene expression signatures for cardiotoxic drugsSemantic proximity Read

SenolyticSynergy: An Attention-Based Network for Discovering Novel Senolytic Combinations via Human Aging GenomicsSemantic proximity Read

KICDB: A Causality-Oriented Multi-Omics Database for Kinase Inhibitor-Induced CardiotoxicitySemantic proximity Read

MultiGML: Multimodal Graph Machine Learning for Prediction of Adverse Drug EventsSemantic proximity Read

Leveraging Neural Network Models for Drug Repurposing: A case study on Cardiac HypertrophySemantic proximity Read

Bridging the Computational-Experimental Gap: Leveraging Large Language Model to Prioritize Alzheimer’s Therapeutics Based on Comparison of Learning ModelsSemantic proximity Read

Advancing Efficacy Prediction for EHR-based Emulated Trials in Repurposing Heart Failure TherapiesSemantic proximity Read