Article

<i>Cirrina</i> : LLM-driven pharmacological reasoning agent enables preclinical CNS drug evaluation

2026-03-31

Abstract excerpt

Assessing whether a preclinical drug candidate will work is not a prediction problem but a reasoning problem. The same numerical output warrants different interpretations depending on the target and therapeutic context. CNS drug development presents the most demanding instance of this reasoning problem. For example, a compound must cross the blood–brain barrier, resist efflux transport, and achieve adequate recept...

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Literature Corpus work: 5e4c0023-e91e-5806-b442-fb5766b49800
DOI: 10.64898/2026.03.29.713781

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