Article

Finding a Place for New Approach Methodologies (NAMs) in Biomedical Research

2025-08-18

Abstract excerpt

New Approach Methodologies (NAMs) can greatly contribute to the Replacement and Reduction of animal experiments in biomedical science. However, while NAMs have seen considerable investment and adoption in toxicology, this growth has not found a parallel in basic and translational biomedical research. Here, we examine the opportunities and the challenges of systematic implementation of NAMs in biomedical research....

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b18e6f0e-e0c5-5439-851c-572bfbedd80b
DOI: 10.32388/l13yba

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Finding a Place for New Approach Methodologies (NAMs) in Biomedical ResearchDOI 10.32388/l13ybaRead

Molecular annotation of AOPs guides the development of the next generation mechanistic chemical safety assessment and new approach methodsSemantic proximity Read

Practical aspects of discovery pathology.Semantic proximity Read

Interpretable AI Decision-Support for Pre-IND Drug Development in a Historically Animal-Approved Cohort: A Large Concept Model FrameworkSemantic proximity Read

Data analysis planning and reporting for confirmatory multi-lab preclinical trialsSemantic proximity Read

Data analysis planning and reporting for confirmatory multi-lab preclinical trialsSemantic proximity Read

In Pursuit of Greater Reproducibility and Credibility of Early Clinical Biomarker ResearchSemantic proximity Read

Mechanistic Research for the Student or Educator (Part I of II)Semantic proximity Read

CSL-Tox: An open-source analytical framework for the comparison of short-term and long-term toxicity end points and exploring the opportunities for decreasing in-vivo studies conducted for drug development programsSemantic proximity Read

Discoveries, therapies and opportunitiesSemantic proximity Read

Task Force on Strategic Research Direction: Clinical Science Subgroup key science topics report.Semantic proximity Read

Planning preclinical confirmatory multicenter trials to strengthen translation from basic to clinical research – a multi-stakeholder workshop reportSemantic proximity Read

A high-throughput method to computationally develop candidate adverse outcome pathways in humans: a proof of concept with insecticides and Parkinson DiseaseSemantic proximity Read