Article

Model-Driven Hybrid AI Framework for End-to-End Autonomous Decision-Making in Drug Development

2026-02-06

Abstract excerpt

Decision-making in drug development spans heterogeneous stages from molecular design to clinical optimization, yet computer-aided workflows across stages remain fragmented, limiting traceability from evidence-derived clinical questions to simulation scenarios and decision endpoints. We present a model-driven hybrid AI framework for end-to-end decision support that treats PICO (Participants, Intervention, Compariso...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 5f79a8d1-42cb-57ba-a4cc-513bee9784c6
DOI: 10.64898/2026.02.03.703154

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Model-Driven Hybrid AI Framework for End-to-End Autonomous Decision-Making in Drug DevelopmentDOI 10.64898/2026.02.03.703154Read

A Proof-of-Concept Study of a Clinical Decision Support System for Vancomycin Therapeutic MonitoringSemantic proximity Read

<i>Cirrina</i> : LLM-driven pharmacological reasoning agent enables preclinical CNS drug evaluationSemantic proximity Read

Prompt-to-Pill: Multi-Agent Drug Discovery and Clinical Simulation PipelineSemantic proximity Read

Using Large Language Models to Assemble, Audit, and Prioritize the Therapeutic LandscapeSemantic proximity Read

Human-supervised Agentic AI for Hypothesis Generation and Experimental Assistance in Drug RepurposingSemantic proximity Read

MechAInistic: A Reviewer-Supervised Multi-Agent LLM System for Auditable Mechanistic Drug-Hypothesis GenerationSemantic proximity Read

MedGenesis: Toward a World Model for Autonomous Clinical and Translational ResearchSemantic proximity Read

An AI-agent-orchestrated grey-box Transformer framework for sparse pharmacokinetic curve reconstruction and pharmacometric model initializationSemantic proximity Read

An interpretable and interactive clinical AI agent for personalized anti-infective decision support in carbapenem-resistant Gram-negative bacterial infectionSemantic proximity Read

PD Union An Automated Pharmacodynamic Modeling Framework Based on a Unified Mechanistic Skeleton and Machine Learning AssistanceSemantic proximity Read

Agentic Trial Emulation to Learn Health System-specific Drug Effects At ScaleSemantic proximity Read

Interpretable AI Decision-Support for Pre-IND Drug Development in a Historically Animal-Approved Cohort: A Large Concept Model FrameworkSemantic proximity Read