Article

Computational design of membrane fusion proteins

2026-05-07

Abstract excerpt

The fusion of two distinct biological membranes is an evolutionarily conserved process essential to cellular organization and physiology. Membrane fusion is driven by the refolding of fusogenic proteins into low-energy postfusion states that overcome the energetic barrier to bilayer merger. Here we report a computational method for the design of synthetic fusogens inspired by the architecture of the soluble N-ethy...

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Identifiers and source

Literature Corpus work: 036fb09f-51e1-536d-8d29-56977e1506e4
DOI: 10.64898/2026.05.04.722779

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