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Article

Statin suppresses Hippo pathway-inactivated malignant mesothelioma cells and blocks the YAP/CD44 growth stimulatory axis.

Cancer letters - 28 Jan 2017

Tanaka Kosuke, Osada Hirotaka, Murakami-Tonami Yuko, Horio Yoshitsugu, Hida Toyoaki, Sekido Yoshitaka

Abstract excerpt

Malignant mesothelioma (MM) frequently exhibits Hippo signaling pathway inactivation (HPI) mainly due to NF2 and/or LATS2 mutations, which leads to the activation of YAP transcriptional co-activator. Here, we show antitumor effects of statin on MM cells with HPI, through the interplay of the mevalonate and Hippo signaling pathways. Statin attenuated proliferation and migration of MM cells harboring NF2 mutation...

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Source

Identifiers

PMID: 27773750
DOI: 10.1016/j.canlet.2016.10.020

Genes

LATS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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