Article

Integrative Transcriptomic Analysis Reveals Tumor-Adjacent Mucosal Remodeling in Colorectal Cancer

2026-06-22

Abstract excerpt

<title>Abstract</title> <p>Tumor-adjacent mucosa is commonly used as a normal reference in colorectal cancer (CRC) transcriptomic studies, but its relationship with distant normal mucosa and tumor tissue remains unclear. Here, we performed bulk RNA sequencing of paired distant normal, adjacent, and tumor tissues from 25 patients with CRC and used these three tissue states to construct an ordered normal–adjacent–t...

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Literature Corpus work: 03635e7f-a57a-5cf7-94c4-0868ceeb786c
DOI: 10.21203/rs.3.rs-9795519/v1

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