Article
Distinct modes of inhibition by sclerostin on bone morphogenetic protein and Wnt signaling pathways.
The Journal of biological chemistry - 31 Dec 2010
Krause Carola, Korchynskyi Olexandr, de Rooij Karien, Weidauer Stella E, de Gorter David J J, van Bezooijen Rutger L, Hatsell Sarah, Economides Aris N, Mueller Thomas D, Löwik Clemens W G M, ten Dijke Peter
Abstract excerpt
Sclerostin is expressed by osteocytes and has catabolic effects on bone. It has been shown to antagonize bone morphogenetic protein (BMP) and/or Wnt activity, although at present the underlying mechanisms are unclear. Consistent with previous findings, Sclerostin opposed direct Wnt3a-induced but not direct BMP7-induced responses when both ligand and antagonist were provided exogenously to cells. However, we found...
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