Article

Phaeochromocytomas and paragangliomas harbour tumour-initiating SOX2+ stem cells

2025-07-07

Abstract excerpt

<h4>ABSTRACT</h4> Phaeochromocytomas (PCCs) and paragangliomas (PGLs), are rare neuroendocrine tumours that arise in the neural crest (NC)-derived adrenal medulla and the paraganglia, respectively. Approximately 10%-15% of patients with PCCs and 35%-40% with PGLs go on to develop metastatic disease, leading to a reported median overall survival of 7 years. The development of prognostic markers and subsequent pers...

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Literature Corpus work: 033816f1-548c-5f8e-b78b-62228d79ac54
DOI: 10.1101/2025.07.03.663006

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