Postnatal Sustentacular Cells as Chromaffin Progenitors and Tumor Cells of Origin in VHL-Related Paragangliomas

Abstract excerpt

<title>Abstract</title> <p>The cellular source of chromaffin cell regeneration after birth and its relationship to paraganglioma tumorigenesis remains incompletely defined. Here, we identify a postnatal population of SOX2/SOX10-expressing sustentacular glia-like cells in the organ of Zuckerkandl (OZ) and adrenal gland that give rise to chromaffin cells <italic>in vivo</italic>. These cells differ transcriptionall...

Topics

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• Adrenal and Paraganglionic Tumors
• Cancer, Hypoxia, and Metabolism
• Congenital heart defects research
• Enteric Nervous System
• Hearing Loss
• Neonatal Respiratory Health Research
• Neuroblastoma Research and Treatments
• Pancreatic function and diabetes

Identifiers and source

Literature Corpus work

6022d75b-1fff-5fe1-99bb-c1d3a2eb4e63

DOI

10.21203/rs.3.rs-6907400/v1