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Article

Role of tissue transglutaminase 2 in the acquisition of a mesenchymal-like phenotype in highly invasive A431 tumor cells.

Molecular cancer - 21 Jul 2011

Lin Chun-Yu, Tsai Pei-Hsun, Kandaswami Chithan C, Chang Geen-Dong, Cheng Chia-Hsiung, Huang Chang-Jen, Lee Ping-Ping, Hwang Jiuan-Jiuan, Lee Ming-Ting

Abstract excerpt

BACKGROUND: Cancer progression is closely linked to the epithelial-mesenchymal transition (EMT) process. Studies have shown that there is increased expression of tissue tranglutaminase (TG2) in advanced invasive cancer cells. TG2 catalyzes the covalent cross-linking of proteins, exhibits G protein activity, and has been implicated in the modulation of cell adhesion, migration, invasion and cancer metastasis. This...

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Identifiers

PMID: 21777419
DOI: 10.1186/1476-4598-10-87
PMCID: PMC3150327

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