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Article

Clinical and biological significance of tissue transglutaminase in ovarian carcinoma.

Cancer research - 15 Jul 2008

Hwang Jee Young, Mangala Lingegowda S, Fok Jansina Y, Lin Yvonne G, Merritt William M, Spannuth Whitney A, Nick Alpa M, Fiterman Derek J, Vivas-Mejia Pablo E, Deavers Michael T, Coleman Robert L, Lopez-Berestein Gabriel, Mehta Kapil, Sood Anil K

Abstract excerpt

Tissue type transglutaminase (TG2) is a unique multifunctional protein that plays a role in many steps in the cancer metastatic cascade. Here, we examined the clinical (n = 93 epithelial ovarian cancers) and biological (in vitro adhesion, invasion, and survival and in vivo therapeutic targeting) significance of TG2 in ovarian cancer. The overexpression of TG2 was associated with significantly worse overall...

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Identifiers

PMID: 18632639
DOI: 10.1158/0008-5472.CAN-07-6130
PMCID: PMC2547344

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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