Article
Integrated Molecular Characterization of Uterine Carcinosarcoma.
Cancer cell - 13 Mar 2017
Cherniack Andrew D, Shen Hui, Walter Vonn, Stewart Chip, Murray Bradley A, Bowlby Reanne, Hu Xin, Ling Shiyun, Soslow Robert A, Broaddus Russell R, Zuna Rosemary E, Robertson Gordon, Laird Peter W, Kucherlapati Raju, Mills Gordon B, Weinstein John N, Zhang Jiashan, Akbani Rehan, Levine Douglas A
Abstract excerpt
We performed genomic, epigenomic, transcriptomic, and proteomic characterizations of uterine carcinosarcomas (UCSs). Cohort samples had extensive copy-number alterations and highly recurrent somatic mutations. Frequent mutations were found in TP53, PTEN, PIK3CA, PPP2R1A, FBXW7, and KRAS, similar to endometrioid and serous uterine carcinomas. Transcriptome sequencing identified a strong epithelial-to-mesenchymal...
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