Profiling bone status indices reveals evidence of a low-turnover bone phenotype in type 2 diabetes: findings from the DiaFALL cohort.

doi:10.1007/s00198-026-07850-9

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Profiling bone status indices reveals evidence of a low-turnover bone phenotype in type 2 diabetes: findings from the DiaFALL cohort.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA - 1 Mar 2026

Rasmussen Nicklas H, Kvist Annika Vestergaard, Bech Asger Ahlmann, Lykkeboe Simon, Starup-Linde Jakob, Handberg Aase, van den Bergh Joop P, Vestergaard Peter

Abstract excerpt

People with type 2 diabetes have increased fracture risk despite preserved bone density. In this matched cross-sectional study, suppressed Bone Status Indices and exploratory sex-related hormonal associations were observed in T2D, indicating altered bone remodeling that is not captured by aBMD alone. These findings support the need for fracture risk assessment approaches that incorporate biochemical markers and...

Topics

Humans
Diabetes Mellitus, Type 2
Female
Bone Density
Male
Biomarkers
Lumbar Vertebrae
Absorptiometry, Photon
Cross-Sectional Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Bone Remodeling

Middle Aged

Aged

Femur Neck

Phenotype

Case-Control Studies

Risk Assessment

Sex Factors

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PMID: 41563408
DOI: 10.1007/s00198-026-07850-9
PMCID: PMC13083425

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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