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Chromosomal Mechanisms of Colistin Resistance in Clinical Isolates of Carbapenem‐Resistant <em>Klebsiella pneumoniae</em> from a Tunisian Tertiary‐Care Hospital

2025-12-02

Abstract excerpt

<h4>Background: </h4> /Objectives: Carbapenem-resistant Klebsiella pneumoniae (CRKP) is a major nosocomial pathogen. Although newer agents have reduced colistin use in high-income countries, this polymyxin remains important in many low- and middle-income settings. Colistin resistance in K. pneumoniae is mainly driven by chromosomal changes in the MgrB–PhoPQ pathway or plasmid-mediated mcr genes. This study aimed t...

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Literature Corpus work
02ccf190-276a-5219-8c2a-d2227fed8327
DOI
10.20944/preprints202512.0173.v1
Open publication

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Chromosomal Mechanisms of Colistin Resistance in Clinical Isolates of Carbapenem‐Resistant <em>Klebsiella pneumoniae</em> from a Tunisian Tertiary‐Care HospitalDOI 10.20944/preprints202512.0173.v1
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