Article
Emergence and clonal spread of colistin resistance due to multiple mutational mechanisms in carbapenemase-producing Klebsiella pneumoniae in London.
Scientific reports - 5 Oct 2017
Otter Jonathan A, Doumith Michel, Davies Frances, Mookerjee Siddharth, Dyakova Eleonora, Gilchrist Mark, Brannigan Eimear T, Bamford Kathleen, Galletly Tracey, Donaldson Hugo, Aanensen David M, Ellington Matthew J, Hill Robert, Turton Jane F, Hopkins Katie L, Woodford Neil, Holmes Alison
Abstract excerpt
Carbapenemase-producing Enterobacteriaceae (CPE) are emerging worldwide, limiting therapeutic options. Mutational and plasmid-mediated mechanisms of colistin resistance have both been reported. The emergence and clonal spread of colistin resistance was analysed in 40 epidemiologically-related NDM-1 carbapenemase producing Klebsiella pneumoniae isolates identified during an outbreak in a group of London hospitals....
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