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Intron retention is a stress response in sensor genes and is restored by Japanese herbal medicines: A basis for future clinical applications

2 May 2022

Abstract excerpt

Intron retention (IR) is a regulatory mechanism that can retard protein production by acting at the level of mRNA processing. We recently demonstrated that IR occurs at the pre-symptomatic state during the aging process of a mouse model of aging, providing a promising biomarker for that state, and can be restored to the normal state by juzentaihoto (JTT), a Japanese herbal medicine (Kampo) (Okada et al. 2021)....

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PMID: 35504437
DOI: 10.1016/j.gene.2022.146496

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