Article

Upregulated Fcrl5 disrupts B cell anergy and causes autoimmunity

2023-07-23

Abstract excerpt

B cell anergy plays a critical role in maintaining self-tolerance by inhibiting autoreactive B cell activation to prevent autoimmune diseases. Here, we demonstrated that Fc receptor-like 5 (Fcrl5) upregulation contributes to autoimmune disease pathogenesis by disrupting B cell anergy. Fcrl5—a gene whose homologs are associated with human autoimmune diseases—is highly expressed in age/autoimmunity-associated B cell...

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Literature Corpus work: 02ae293e-20a4-5a13-9581-dcf069f472eb
DOI: 10.1101/2023.07.20.549843

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