Article
FcγRIIB and autoimmunity.
Immunological reviews - 1 Jan 2016
Espéli Marion, Smith Kenneth G C, Clatworthy Menna R
Abstract excerpt
Autoimmune diseases are characterized by adaptive immune responses against self-antigens, including humoral responses resulting in the production of autoantibodies. Autoantibodies generate inflammation by activating complement and engaging Fcγ receptors (FcγRs). The inhibitory receptor FcγRIIB plays a central role in regulating the generation of autoantibodies and their effector functions, which include...
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