Article

<i>Dnajc3</i> (HSP40) Enhances Axon Regeneration in the Mouse Optic Nerve

2024-10-12

Abstract excerpt

<h4>ABSTRACT</h4> A forward genetics approach was used to identify genomic elements enhancing axon regeneration in the BXD recombinant mouse strains. Axon regeneration was induced by knocking down Pten in retinal ganglion cells (RGCs) using adeno-associated virus (AAV) to deliver an shRNA followed by an intravitreal injection of Zymosan with CPT-cAMP that produced a mild inflammatory response. RGC axons were dam...

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Literature Corpus work: 02559f03-1515-5a56-8eaf-b8643accd6f1
DOI: 10.1101/2024.10.08.617251

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