Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Systems Genetics of Optic Nerve Axon Necrosis During Glaucoma

27 Feb 2020

Abstract excerpt

In this study we identify genomic regions that modulate the number of necrotic axons in optic nerves of a family of mice, some of which have severe glaucoma, and define a set of high priority positional candidate genes that modulate retinal ganglion cell (RGC) axonal degeneration. A large cohort of the BXD family were aged to greater than 13 months-of-age. Optic nerves from 75 strains and the DBA/2J (D2) parent...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Glaucoma and retinal disorders
Share to Retinal Development and Disorders
Share to Retinal Diseases and Treatments

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 32174956
DOI: 10.3389/fgene.2020.00031

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Systems Genetics of Optic Nerve Axon Necrosis During GlaucomaPMID 32174956Read ↗

Rgcs1, a dominant QTL that affects retinal ganglion cell death after optic nerve crush in mice.Semantic proximity Read ↗

Commonalities of optic nerve injury and glaucoma-induced neurodegeneration: Insights from transcriptome-wide studiesSemantic proximity Read ↗

Retinal Genomic Fabrics Remodeling after Optic Nerve InjurySemantic proximity Read ↗

Optic neuropathies: the tip of the neurodegeneration icebergSemantic proximity Read ↗

Insights on the Genetic and Phenotypic Complexities of Optic Neuropathies.Semantic proximity Read ↗

Candidate Genetic Modifiers for RPGR Retinal Degeneration.Semantic proximity Read ↗

High throughput functional profiling of genes at intraocular pressure loci reveals distinct networks for glaucomaSemantic proximity Read ↗

Spink2 modulates apoptotic susceptibility and is a candidate gene in the Rgcs1 QTL that affects retinal ganglion cell death after optic nerve damage.Semantic proximity Read ↗

Impaired axonal transport at the optic nerve head contributes to neurodegeneration in a novel Cre-inducible mouse model of myocilin glaucomaSemantic proximity Read ↗

From Transcriptomics to Treatment in Inherited Optic Neuropathies.Semantic proximity Read ↗

Systems Genetics Analysis to Identify the Genetic Modulation of a Glaucoma-Associated Gene.Semantic proximity Read ↗

Differential response of C57BL/6J mouse and DBA/2J mouse to optic nerve crush.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.