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Germline HLA-DQ genotype influences response to CAR T-cell therapy in patients with large B-cell lymphoma

2024-01-12

Abstract excerpt

CD19-directed chimeric antigen receptor (CAR) T cells have greatly improved the prognosis of relapsed/refractory large B-cell lymphoma (rrLBCL), yet treatment failure occurs in more than half of patients, usually in the first 3 months after treatment. While they primarily act through CAR-dependent, HLA-independent recognition of tumor targets, CAR-T cells may also indirectly contribute to long-term tumor immunosur...

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Literature Corpus work
0250130a-39e7-5d23-b50a-9cc9e83fc510
DOI
10.1101/2024.01.11.24301087
Open publication

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Germline HLA-DQ genotype influences response to CAR T-cell therapy in patients with large B-cell lymphomaDOI 10.1101/2024.01.11.24301087
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